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AZD9496 maleate
CAS No. 1639042-28-6
AZD9496 maleate ( AZD-9496 maleate )
Catalog No. M12478 CAS No. 1639042-28-6
A potent, selective estrogen receptor downregulator (SERD) with ER downregulation pIC50 of 9.68.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 806 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameAZD9496 maleate
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective estrogen receptor downregulator (SERD) with ER downregulation pIC50 of 9.68.
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DescriptionA potent, selective estrogen receptor downregulator (SERD) with ER downregulation pIC50 of 9.68; shows pM equipotent binding to both ERα and ERβ isoforms, highly selective binding compared with progesterone (～650-fold), glucocorticoid (～11,223-fold), and androgen (～36,375-fold) receptor LBDs; downregulator of ERα in vitro and in vivo in ER-positive models of breast cancer and orally available. Breast Cancer Phase 1 Clinical
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SynonymsAZD-9496 maleate
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PathwayEndocrinology/Hormones
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TargetEstrogen Receptor/ERR
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RecptorEstrogen Receptor/ERR
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Research AreaCancer
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IndicationBreast Cancer
Chemical Information
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CAS Number1639042-28-6
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Formula Weight558.55
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Molecular FormulaC29H29F3N2O6
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCC1CC2=C(C(N1CC(C)(C)F)C3=C(C=C(C=C3F)C=CC(=O)O)F)NC4=CC=CC=C24.C(=CC(=O)O)C(=O)O
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Chemical Name2-Propenoic acid, 3-[3,5-difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]phenyl]-, (2E)-, (2Z)-2-butenedioate (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. De Savi C, et al. J Med Chem. 2015 Oct 22;58(20):8128-40.
2. Weir HM, et al. Cancer Res. 2016 Jun 1;76(11):3307-18.
3. Toy W, et al. Cancer Discov. 2017 Mar;7(3):277-287.
2. Weir HM, et al. Cancer Res. 2016 Jun 1;76(11):3307-18.
3. Toy W, et al. Cancer Discov. 2017 Mar;7(3):277-287.
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